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Advanced functional materials: palladium loaded npmof combined with hydrogen / photodynamic therapy to enhance tumor inhibition

wallpapers News 2020-12-04

hydrogen is considered as an ideal clean energy. Hydrogen has been developed for biomedical applications due to its high safety selective antioxidant capacity. Studies have shown that hydrogen can treat a variety of diseases especially oxidative stress-related diseases such as tissue inflammation Alzheimer's disease Parkinson's disease myocardial ischemia-reperfusion injury so on. In recent years hydrogen therapy has received more more attention in the field of anti-tumor research. Studies have shown that reductive hydrogen can selectively reduce the over expression of hydroxyl radicals (· oh) in tumor microenvironment interfere with the redox homeostasis of tumor microenvironment induce redox stress cell destruction apoptosis; while hydrogen can maintain the level of reactive oxygen species (ROS) in normal cells prevent the cells from oxidative damage. On the other h photodynamic therapy (PDT) as a non-invasive treatment of ROS has been approved for the treatment of many types of tumors. The principle of inducing apoptosis of cells is the destruction of oxygen molecule oxygen molecule to specific wavelength. PDT has high safety it can achieve local treatment by non-toxic harmless external light localization it can use the fluorescence characteristics of photosensitizer to guide the treatment. Therefore can we combine the delivery of reduced hydrogen with the production of light-induced 1O2 to disrupt the redox balance in tumor cells to achieve safe effective tumor therapy? To this end Zhu Yufang a researcher collaborator of Shanghai Institute of silicate Chinese Academy of Sciences designed synthesized a biocompatible palladium nanocrystalline supported nano porphyrin metal organic framework (npmof) to realize a new combined therapy mode hydrogen / photodynamic therapy.

npmof have high biocompatibility abundant micropores. The skeleton contains a large number of porphyrin photosensitizer ligs which can realize the photoinduced production of 1O2 for PDT. PD nanocrystals were loaded on npmof by in-situ reduction method the synthesized nanoparticles were loaded with hydrogen by self-made hydrogen generating device. Due to the high hydrogen affinity catalytic hydrogenation ability of PD PD nanocrystals supported on npmof can achieve effective hydrogen delivery. The results show that the final nanosystems exhibit high hydrogen storage capacity sustained reductive hydrogen release performance light can induce a large amount of 1O2 production without the influence of reductive hydrogen delivery. Furthermore they confirmed that reductive hydrogen delivery nanosystems can induce cell death by interfering with redox homeostasis increasing the oxidative pressure in tumor cells while maintaining normal redox levels in normal cells thus achieving tumor selective hydrogen therapy. It is worth noting that when the nano system of reductive hydrogen delivery enters the tumor cells it can further increase the oxidative pressure in the cells through light induced 1O2 production resulting in enhanced oxidative damage. Finally by combining tumor selective hydrogen therapy photodynamic therapy the designed PD loaded npmof nano system can achieve synergistic enhancement of anti-tumor effect without obvious side effects which provides a reference for future efficient safe tumor treatment.


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