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Small: targeted clearance and detection of amyloid beta in Alzheimer's disease by nitrogen doped carbonized polymer

wallpapers News 2020-07-24

Alzheimer's disease (AD) is an irreversible chronic neurodegenerative disease which can lead to progressive memory loss cognitive impairment personality changes so on. By 2016 47 million people around the world were suffering from AD more than the total population of Spain 3.4% of the population of China. The number is expected to reach 150 million by 2050. Ad also brings huge social economic burden. It is estimated that the cost of ad in the world will reach more than 9 trillion US dollars in 2050. The pathological features of AD are the accumulation of amyloid β - protein (a β) outside nerve cells the tangle of nerve fibers inside nerve cells. A β is a product of the cleavage of amyloid precursor protein by β - γ - secretase. The formation of a β fibrils from soluble monomers to toxic a β oligomers fibrils is considered to be directly related to synaptic dysfunction neuronal death nervous system disorders. Therefore clearance detection of amyloid aggregates are essential for the treatment diagnosis of AD.

Professor Sun Yan his research team of Tianjin University School of chemical engineering have made important progress in the removal detection of amyloid beta protein aggregates. They found that nitrogen doped carbonized polymer dots (CPDS) a kind of 5 nm carbon dots synthesized by hydrothermal method have red fluorescence strongly inhibit a β aggregation rapidly depolymerize mature a β fibers realize real-time fluorescence detection of a β plaque. The results showed that 100 μ g / ml CPDs could inhibit the formation of a β fibers by 74%. CPDs can rapidly destroy a β fibers from seconds to minutes 100 μ g / ml CPDs can depolymerize more than 90% of a β fibers in 4 hours. CPDs can label a β aggregation plaque in vitro in vivo. At the same time CPDs could remove amyloid plaques prolong the life span of C. elegans cl2006 by 6 days. Detailed mechanism analysis shows that the multiple interactions between the positively charged amino groups in CPD the negatively charged residues in a β as well as between the conjugated π system of CPD the hydrophobic core of a β are the main factors that inhibit the aggregation of a β rapidly remove the aggregation plaque of a β.

show exciting prospects in the treatment diagnosis of AD provide a new perspective for the development of carbon nanomaterials in the diagnosis treatment. The related work was published in small (DOI: 10.1002 / small. 202002804).


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