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Small: ultra small gold nanoparticles / 2D MOFs hybrid nanoenzyme for highly effective antibacterial therapy

wallpapers News 2020-11-23

infectious diseases are increasingly harmful to human health. And the common antibiotic treatment long-term use may cause drug resistance problems. Nano enzyme is a kind of nano materials similar to natural enzyme catalytic properties. Peroxidase like nano materials can actively promote the antibacterial effect of H2O2 avoid the toxicity of high concentration of H2O2. It is a kind of nano enzyme with great advantages which has attracted more more attention in the field of antibacterial treatment.

recently the research group of Wang Chen of China Pharmaceutical University Professor Xia Xinghua of Nanjing University have made new progress in the design manufacture antibacterial application of nano enzyme materials. They used 2D MOFs as substrates to grow gold nanoparticles in situ. The interaction between porphyrin n n group usannps in MOFs ligs can inhibit the aggregation of usannps which limits the continuous growth of gold nanoparticles. Combined with the spatial confinement effect of MOFs ultra small gold nanoparticles (usannps) with stable size were prepared. The results showed that the material showed a significant peroxidase like activity which could promote the decomposition of H2O2 into toxic hydroxyl radical (· oh). With the assistance of low dose of H2O2 it showed good antibacterial activity against Gram-negative bacteria (Escherichia coli) Gram-positive bacteria (Staphylococcus aureus). Animal experiments show that the nano enzyme can effectively promote wound healing the material has good biocompatibility. This study reveals the potential application value of the composite in antibacterial therapy.


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